Australia 98 for 4 (Perry 35*) beat Bangladesh 97 (Molineux 3-10) by six wickets
Molineux, in her first ODI since 2021, claimed 3 for 10 from 10 overs to help bowl Bangladesh out for 97 in 44.1 overs in Mirpur.
Australia were 39 for 3 in the 13th over of the chase but got home comfortably to take a 2-0 lead in the three-game series.
Molineux returned to the Australian set-up last month for the first time since October 2021 after suffering a foot stress fracture and then a ruptured anterior cruciate ligament in a knee.
After being overlooked for game one of the Bangladesh series, the 26-year-old on Sunday produced a top-shelf spell of left-arm spin bowling which included five maiden overs.
Molineux claimed three of the initial five wickets to fall and Bangladesh at one stage had slipped to 61 for 8 in the 32nd over.
Her feats came as Megan Schutt, Ashleigh Gardner, Georgia Wareham and Alana King collectively overwhelmed the Bangladesh batters.
Phoebe Litchfield’s lean run continued when she was run out for 5 while Tahlia McGrath also went the same way. But Perry combined with Gardner to steer the Australians to a comfortable victory.
Australia won the opening ODI by 118 runs three days ago with Wednesday’s third game to be followed by three T20Is.